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Immunogen sequence: MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP SAFLELKKEE IKQRQIEQEK LASMKKQDED KDKRDKEEKE; Positive Samples: HT-29, OVCAR-3, LO2, HeLa, Jurkat, Mouse liver, Mouse kidney; Cellular Location: Nucleus matrix, Nucleus speckle
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Plenty-of-prolines 101; plenty-of-prolines-101; Ser/Arg-related nuclear matrix protein; serine/arginine repetitive matrix 1; Serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kDa; SRm160
基因别名: 160-KD; AA407769; POP101; SRM160; SRRM1
UniProt ID: (Human) Q8IYB3, (Mouse) Q52KI8
Entrez Gene ID: (Human) 10250, (Mouse) 51796
分子生物学功能:
RNA metabolism protein
RNA processing factor
nucleic acid metabolism protein
