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产品信息
PA5-50833
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:100-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to residues near the C terminal of human synovial sarcoma, X breakpoint 4 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636285 |
产品详细信息
The antibody detects endogenous levels of total SSX4 protein.
靶标信息
SSX4 belongs to the SSX family. It contains 1 KRAB-related domain. SSX4 could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
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生物信息学
蛋白别名: Cancer/testis antigen 5.4; CT5.4; MGC119056; MGC12411; Protein SSX4; synovial sarcoma, X breakpoint 4
基因别名: CT5.4; SSX4; SSX4A; SSX4B
UniProt ID: (Human) O60224
Entrez Gene ID: (Human) 6759
