Immunogen sequence: PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLSDQLAGKI LVDVSNPTEQ EHLQHRE
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
蛋白别名: dudlin 2; Dudulin-2; hpHyde; hTSAP6; Metalloreductase STEAP3; pHyde; Six-transmembrane epithelial antigen of prostate 3; STEAP family member 3, metalloreductase; tumor suppressor pHyde; Tumor suppressor-activated pathway protein 6
基因别名: AHMIO2; dudlin-2; dudulin-2; pHyde; STEAP3; STMP3; TSAP6
UniProt ID: (Human) Q658P3
Entrez Gene ID: (Human) 55240