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Positive Control: 293T, AGS, Hela, human kidney tissue, human placenta tissue, mouse testis tissue.
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: OTTHUMP00000123457; OTTHUMP00000123458; OTTHUMP00000216198; Stromal interaction molecule 2
基因别名: KIAA1482; STIM2
UniProt ID: (Human) Q9P246
Entrez Gene ID: (Human) 57620