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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1.0 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
synthetic peptide directed towards the C-terminal region of rat STING |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS with 2% sucrose |
内含物 |
0.09% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2689650 |
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: mitochondrial transmembrane protein 173; rSTING; Stimulator of interferon genes protein; tm173; Transmembrane protein 173
基因别名: RGD1562552; Sting1; Tmem173
UniProt ID: (Rat) F1M391
Entrez Gene ID: (Rat) 498840
