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Proteintech
STK38 Polyclonal Antibody
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产品信息
11105-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
STK38 Fusion Protein Ag1559 (116-465 aa encoded by BC012085)
偶联物
形式
Liquid
浓度
0.27 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody recognizes the C-terminal of STK38.
Immunogen sequence: AMKILRKAD MLEKEQVGHI RAERDILVEA DSLWVVKMFY SFQDKLNLYL IMEFLPGGDM MTLLMKKDTL TEEETQFYIA ETVLAIDSIH QLGFIHRDIK PDNLLLDSKG HVKLSDFGLC TGLKKAHRTE FYRNLNHSLP SDFTFQNMNS KRKAETWKRN RRQLAFSTVG TPDYIAPEVF MQTGYNKLCD WWSLGVIMYE MLIGYPPFCS ETPQETYKKV MNWKETLTFP PEVPISEKAK DLILRFCCEW EHRIGAPGVE EIKSNSFFEG VDWEHIRERP AAISIEIKSI DDTSNFDEFP ESDILKPTVA TSNHPETDYK NKDWVFINYT YKRFEGLTAR GAIPSYMKAA K (116-465 aa encoded by BC012085)
靶标信息
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
