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产品信息
PA5-50836
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:25-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to residues near the C terminal of human ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
2.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636288 |
产品详细信息
The antibody detects endogenous levels of total ABCC8 protein.
靶标信息
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
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生物信息学
蛋白别名: AM60008PU-N; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; PH SUR1; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1
基因别名: ABC36; ABCC8; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2
UniProt ID: (Human) Q09428
Entrez Gene ID: (Human) 6833
potassium ion transport
signal transduction
response to pH
response to zinc ion
response to lipopolysaccharide
response to insulin
response to drug
positive regulation of potassium ion transport
negative regulation of insulin secretion
regulation of insulin secretion
transmembrane transport
cellular response to organic substance
potassium ion transmembrane transport
anion transmembrane transport
