Invitrogen

SYPL2 Polyclonal Antibody

Name: SYPL2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-20776
Availability: InStock

查看其他3个SYPL2抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (3)

SYPL2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

SYPL2 Antibody (PA5-20776) in ICC/IF

Immunofluorescence of SYPL2 in Human Spleen cells with SYPL2 Polyclonal Antibody (Product # PA5-20776) at 20 µg/mL.

SYPL2 Antibody in Immunohistochemistry (IHC)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image SYPL2 Polyclonal Antibody

产品信息

PA5-20776

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化 (IHC)

2.5 µg/mL

免疫细胞化学 (ICC/IF)

20 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 15 amino acid peptide near the carboxy terminus of human SYPL.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_11152294

产品详细信息

A suggested positive control is human spleen tissue lysate.

PA5-20776 can be used with blocking peptide PEP-0890.

靶标信息

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.

仅用于科研。不用于诊断过程。未经明确授权不得转售。