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A suggested positive control is human spleen tissue lysate.
PA5-20776 can be used with blocking peptide PEP-0890.
SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Mg29; mitsugumin 29; Mitsugumin-29; mitsugumin29; synaptophysin-like 2; Synaptophysin-like protein 2; UNQ6348
基因别名: AI552439; MG29; SYPL2
UniProt ID: (Human) Q5VXT5, (Mouse) O89104
Entrez Gene ID: (Human) 284612, (Mouse) 17306, (Rat) 362018