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产品信息
PA5-50794
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length fusion protein of Human SRGN
偶联物
Unconjugated
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636246
产品详细信息
The antibody detects endogenous levels of total Serglycin protein.
靶标信息
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
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生物信息学
蛋白别名: hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; Hematopoietic proteoglycan core protein; P.PG; Platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; Serglycin; serglycin proteoglycan
基因别名: PPG; PRG; PRG1; SRGN
UniProt ID: (Human) P10124
Entrez Gene ID: (Human) 5552
platelet degranulation
granzyme-mediated apoptotic signaling pathway
protein processing
negative regulation of bone mineralization
biomineral tissue development
mast cell secretory granule organization
protease localization to mast cell secretory granule
T cell secretory granule organization
maintenance of protease location in mast cell secretory granule
maintenance of granzyme B location in T cell secretory granule
negative regulation of cytokine secretion
