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Rockland
Spectrin (alpha and beta) Monoclonal Antibody (SB-SP1)
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产品信息
200-301-P46
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
SB-SP1
抗原
Spectrin(alpha and beta) antibody was produced in mice by repeated immunizations with human erythrocyte spectrin.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
1.2% sodium acetate with 2mg BSA
内含物
0.01% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Spectrin is a cytoskeletal protein crucial for maintaining the structural integrity and flexibility of cell membranes, especially in erythrocytes. Spectrin consists of alpha and beta subunits that form heterodimers, which further assemble into tetramers at the cell membrane. The alpha subunit genes include SPTA1 and SPTAN1, and the beta subunits are encoded by four conventional genes: SPTB, SPTBN1, SPTBN2, and SPTBN4. Spectrin's modular structure comprises spectrin repeats, integral to its function as a scaffold for various cellular components. It interacts with other proteins such as actin and ankyrin, stabilizing cells against mechanical stress. Spectrin is ubiquitous in different cell types and plays a role in signaling pathways, cellular morphology, and intracellular transport. Pathogenic variants in spectrin genes can lead to neurological disorders due to their role in the nervous system's organization. While primarily known for its function in erythrocytes, spectrin's role in cellular matrix organization positions it as a target for research in cell biology and disease mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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