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Invitrogen
Spironolactone Recombinant Mouse Monoclonal Antibody (5A5)
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Spironolactone Antibody (MA566309) in SDS-PAGE
SDS-PAGE characterization of Spironolactone under reducing conditions. Lane M: Protein marker (kDa); Lane CRN: Purified Spironolactone Recombinant Monoclonal (Product # MA566309). Spironolactone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-649.
产品信息
MA566309
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5A5
抗原
Conjugate of CRN hapten and KLH.
偶联物
形式
Liquid
浓度
3.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Spironolactone is a synthetic steroid that functions as a potassium-sparing diuretic and antihypertensive agent, primarily used to treat conditions such as heart failure, hypertension, and certain cases of hyperaldosteronism. It works by antagonizing the action of aldosterone, a hormone that increases sodium reabsorption in the kidneys, thus promoting the excretion of sodium and water while retaining potassium. The molecular structure of spironolactone includes a lactone ring, which is crucial for its binding to the mineralocorticoid receptor. Spironolactone is metabolized in the liver, and its active metabolites contribute to its therapeutic effects. Recent studies have explored its topical application using polymeric nanoparticles for targeted delivery in treating conditions like acne and alopecia, enhancing its efficacy and safety profile. Bioequivalence studies have been conducted to compare different formulations of spironolactone, ensuring consistent therapeutic outcomes across various products.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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