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Invitrogen
Synapsin 1/2 Recombinant Rabbit Monoclonal Antibody (PSH10-29)
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Synapsin 1/2 Antibody (MA562922) in ICC/IF
Immunofluorescence analysis of Synapsin 1/2 was performed using IMR-32 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Synapsin 1/2 Recombinant Rabbit Monoclonal Antibody (PSH10-29) (Product # MA562922) at 1:100 in 0.1% BSA, incubated at 4 degree celsiu... View More
产品信息
MA562922
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH10-29
抗原
Recombinant protein within human Synapsin I aa 1-705.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: Mouse brain tissue lysate, Rat brain tissue lysate, mouse primary neuronal, human brain tissue, mouse brain tissue, mouse retina tissue, rat brain tissue, rat retina tissue.
Tissue Specificity: Tissue enriched (brain)
Subcellular Location: Synapse, Golgi apparatus, Presynapse, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Sequence Similarities: 95% Mouse,Rat
Predicted band size: 62 kDa.
靶标信息
The SYN1 gene, located on chromosome Xp11.3-p11.23, encodes synapsin I, a neuronal phosphoprotein critical for the regulation of synaptic vesicle release and neurotransmitter mediation. Synapsin I is involved in synaptic plasticity and the maintenance of synaptic vesicle pools, modulating neurotransmission and synaptic strength. The SYN2 gene, located on chromosome 3p25-p26, encodes synapsin II, another protein that plays a similar role in synaptic vesicle trafficking and neurotransmitter release. Both synapsin I and II are essential for proper neuronal function and are highly expressed in the brain. Dysregulations or mutations in these genes can be associated with neurological disorders such as epilepsy and schizophrenia, indicating their importance in maintaining the integrity of neural networks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain protein 4.1; synapsin 1; synapsin 2; Synapsin I; Synapsin II; Synapsin-1; Synapsin-2; truncated synapsin 1-S
基因别名: 2900074L19Rik; AI836018; AI841723; Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYN2; SYNI; SYNII
UniProt ID: (Human) P17600, (Human) Q92777, (Rat) P09951, (Mouse) O88935, (Mouse) Q64332, (Rat) Q63537
Entrez Gene ID: (Human) 6853, (Human) 6854, (Rat) 24949, (Mouse) 20964, (Mouse) 20965, (Rat) 29179
