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Invitrogen
T-bet Polyclonal Antibody
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产品信息
PA5-28881
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human TBX21. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG.
Predicted reactivity: Mouse (96%), Rat (97%), Pig (97%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HGNC:11599; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
基因别名: T-bet; T-PET; TBET; TBLYM; TBX21
UniProt ID: (Human) Q9UL17
Entrez Gene ID: (Human) 30009
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
response to virus
T cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of isotype switching to IgG isotypes
cellular response to organic substance
lymphocyte migration
