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产品信息
700059
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
5-7 µg/mL | - |
免疫组化 (IHC) |
- | 查看1篇已发表文章 1篇已发表文章 |
免疫组化（石蜡） (IHC (P)) |
4-6 µg/mL | - |
免疫细胞化学 (ICC/IF) |
8-12 µg/mL | - |
流式细胞分析 (Flow) |
- | 查看1篇已发表文章 1篇已发表文章 |
| 产品规格 | |
|---|---|
种属反应 |
Human |
已发表种属 |
Bovine, Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Recombinant Monoclonal |
类型 |
Antibody |
克隆号 |
16H4L5 |
抗原 |
A peptide corresponding to amino acids 520-535 of Q9UL17. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS |
内含物 |
0.09% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2532279 |
产品详细信息
This antibody is predicted to react with bovine, canine, chimpanzee, equine, mouse, rat and Rhesus monkey based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HGNC:11599; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
基因别名: T-bet; T-PET; TBET; TBLYM; TBX21
UniProt ID: (Human) Q9UL17
Entrez Gene ID: (Human) 30009
分子生物学功能:
Rel homology transcription factor
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
response to virus
T cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of isotype switching to IgG isotypes
cellular response to organic substance
lymphocyte migration
