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Immunogen sequence: QALLKGPLMC NSPSNSNANC EFSLKNISDI
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 60%.
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Transmembrane 4 L6 family member 20
基因别名: PRO994; SLI5; TCCE518; TM4SF20; UNQ518/PRO994
UniProt ID: (Human) Q53R12
Entrez Gene ID: (Human) 79853