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Proteintech
TAB2 Recombinant Rabbit Monoclonal Antibody (230118F1)
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产品信息
82948-5-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
230118F1
抗原
TAB2 fusion protein Ag5742
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: SGPRTSSTSS SVNSQTLNRN QPTVYIAASP PNTDELMSRS QPKVYISANA ATGDEQVMRN QPTLFISTNS GASAASRNMS GQVSMGPAFI HHHPPKSRAI GNNSATSPRV VVTQPNTKYT FKITVSPNKP PAVSPGVVSP TFELTNLLNH PDHYVETENI QHLTDPTLAH VDRISETRKL SMGSDDAAYT QALLVHQKAR MERLQRELEI QKKKLDKLKS EVNEMENNLT RRRLKRSNSI SQIPSLEEMQ QLRSCNRQLQ IDIDCLTKEI DLFQARGPHF NPSAIHNFYD NIGFVGPVPP KPKDQRSIIK TPKTQDTEDD EGAQWNCTAC TFLNHPALIR CEQCEMPRHF
靶标信息
TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21885; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; OTTHUMP00000017388; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
基因别名: 1110030N06Rik; A530078N03Rik; CHTD2; KIAA0733; MAP3K7IP2; mKIAA0733; TAB-2; TAB2
UniProt ID: (Human) Q9NYJ8, (Mouse) Q99K90
Entrez Gene ID: (Human) 23118, (Mouse) 68652
heart development
positive regulation of protein kinase activity
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
negative regulation of autophagy
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
nucleotide-binding oligomerization domain containing signaling pathway
