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Invitrogen
TAS2R38 Polyclonal Antibody
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TAS2R38 Antibody (PA5-90212) in WB
Western blot analysis of TAS2R38 in extracts of Rat thymus. Samples were incubated with TAS2R38 Polyclonal antibody (Product # PA5-90212) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-90212
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_7897874)
偶联物
形式
Liquid
浓度
0.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: CSCICTVLCV WCFFSRPHFT VTTVLFMNNN TRLNWQIKDL NLFYSFLFCY LWSVPPFLLF LVSSGMLTVS LGRHMRTMKV YTRNSRDPSL EAHIKALKSL V; Positive Samples: rat thymus; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting); also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: T2R26; T2R38; T2r38 {ECO:0000312|RGD:1560649}; Taste receptor type 2 member 138; Taste receptor type 2 member 26; Taste receptor type 2 member 38; taste receptor, type 2, member 38
基因别名: T2R38; Tas2r138; Tas2r26; Tas2r38
UniProt ID: (Rat) Q4VHE7
Entrez Gene ID: (Rat) 500091
