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Invitrogen
TATDN3 Polyclonal Antibody
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产品信息
PA5-56922
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AGVGLVDCHC HLSAPDFDRD LDDVLEKAKK ANVVALVAVA EHSGEFEKIM QLSERYNGFV LPCL
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 28%.
靶标信息
The TATDN3 gene encodes the protein TatD DNase domain containing 3, which belongs to a family of nucleases with a range of enzymatic activities. TATDN3 is known to exhibit apurinic/apyrimidinic (AP) endonuclease activity, which is crucial for DNA repair mechanisms, particularly in the recognition and removal of damaged bases. Structurally, the TatD family proteins, including TATDN3, possess a conserved nuclease domain that enables their function in DNA metabolism. Studies demonstrate that TATDN3 can also display 3'-5' exonuclease activity, further contributing to genome stability by processing DNA ends. Phylogenetically, TATDN3 represents a distinct clade with unique active site motifs, differentiating it from other paralogs such as TATDN1. Given its involvement in critical cellular processes, TATDN3 is an important factor in maintaining genomic integrity and preventing mutations that may lead to diseases such as cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Putative deoxyribonuclease TATDN3
基因别名: TATDN3
UniProt ID: (Human) Q17R31
Entrez Gene ID: (Human) 128387
