Immunogen sequence: DWELKTQQPL MLKNQLLTLK IKYPHQLDQK VLEKQLPGSM TIQKVKGLLS RLLKVPVSDL LLSYESPKKP GREIELENDL KSLQFYSVEN GDCLLVRW
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
蛋白别名: hypoparathyroidism, growth and mental retardation, and dysmorphism; Tubulin-folding cofactor E; Tubulin-specific chaperone E
基因别名: HRD; KCS; KCS1; pac2; TBCE
UniProt ID: (Human) Q15813
Entrez Gene ID: (Human) 6905