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Proteintech
TBX21/T-bet Polyclonal Antibody
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产品信息
13700-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TBX21,T-bet Fusion Protein Ag4618 (1-328 aa encoded by BC039739)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGIVEPGCG DMLTGTEPMP GSDEGRAPGA DPQHRYFYPE PGAQDADERR GGGSLGSPYP GGALVPAPPS RFLGAYAYPP RPQAAGFPGA GESFPPPADA EGYQPGEGYA APDPRAGLYP GPREDYALPA GLEVSGKLRV ALNNHLLWSK FNQHQTEMII TKQGRRMFPF LSFTVAGLEP TSHYRMFVDV VLVDQHHWRY QSGKWVQCGK AEGSMPGNRL YVHPDSPNTG AHWMRQEVSF GKLKLTNNKG ASNNVTQMIV LQSLHKYQPR LHIVEVNDGE PEAACNASNT HIFTFQETQF IAVTAYQNAE ITQLKIDNNP FAKGFRENF (1-328 aa encoded by BC039739 )
靶标信息
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HGNC:11599; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
基因别名: T-bet; T-PET; TBET; TBLYM; TBT1; TBX21
UniProt ID: (Human) Q9UL17, (Mouse) Q9JKD8
Entrez Gene ID: (Human) 30009, (Mouse) 57765
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
response to virus
T cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of isotype switching to IgG isotypes
cellular response to organic substance
lymphocyte migration
regulation of immune response
