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Abnova
TCF3 Monoclonal Antibody (5G2)
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产品信息
H00006929-M01A
产品规格
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
5G2
抗原
TCF3 (NP_003191, 545 a.a. approximately 654 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: EREKERRVAN NARERLRVRD INEAFKELGR MCQLHLNSEK PQTKLLILHQ AVSVILNLEQ QVRERNLNPK AACLKRREEE KVSGVVGDPQ MVLSAPHPGL SEAHNPAGHM
靶标信息
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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