Proteintech

TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488

产品信息

CL488-67652

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

0.4 µg/1x10^6 cell suspension
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

2B2D12

抗原

Recombinant protein
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偶联物

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

激发/发射光谱

493/522 nm

形式

Liquid

纯化类型

Protein A

保存液

PBS with 50% glycerol, 0.5% BSA

内含物

0.05% ProClin 300

保存条件

-20°C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: MPQLGGGGGG GGGSGGGGGS SAGAAGGGDD LGANDELIPF QDEGGEEQEP SSDSASAQRD LDEVKSSLVN ESENQSSSSD SEAERRPQPV RDTFQKPRDY FAEVRRPQDS AFFKGPPYPG YPFLMIPDLS SPYLSNGPLS PGGARTYLQM KWPLLDVPSS ATVKDTRSPS PAHLSNKVPV VQHPHHMHPL TPLITYSNDH

靶标信息

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HMG box transcription factor 3; HMG box transcription factor 4; hTCF-4; mTCF-4; T-cell factor 3; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-3; TCF7L1/2; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG box); transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box

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基因别名: bHLHb21; mTcf-4B; mTcf-4E; TCF-3; TCF-4; TCF3; TCF4; TCF4B; TCF4E; TCF7L1; TCF7L2

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UniProt ID: (Human) Q9HCS4, (Human) Q9NQB0, (Mouse) Q9Z1J1, (Mouse) Q924A0

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Entrez Gene ID: (Human) 83439, (Human) 6934, (Mouse) 21415, (Mouse) 21416

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功能
DNA binding transcription factor activity, sequence-specific DNA binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding protein binding transcription factor binding protein kinase binding nuclear hormone receptor binding gamma-catenin binding armadillo repeat domain binding chromatin binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor
参与通路
chromatin organization transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of Wnt signaling pathway canonical Wnt signaling pathway beta-catenin-TCF complex assembly negative regulation of transcription from RNA polymerase II promoter blood vessel development cell cycle arrest Wnt signaling pathway, calcium modulating pathway cell proliferation response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process pancreas development positive regulation of insulin secretion positive regulation of protein binding regulation of hormone metabolic process glucose homeostasis negative regulation of sequence-specific DNA binding transcription factor activity maintenance of DNA repeat elements canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of protein export from nucleus myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of protein kinase B signaling negative regulation of canonical Wnt signaling pathway negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway anterior/posterior axis specification, embryo Wnt signaling pathway somatic stem cell population maintenance skin development positive regulation of transcription from RNA polymerase II promoter during mitosis axial mesoderm morphogenesis generation of neurons stem cell differentiation regulation of stem cell population maintenance cellular glucose homeostasis glycogen metabolic process glucose metabolic process transcription from RNA polymerase II promoter cellular response to starvation post-embryonic development positive regulation of triglyceride biosynthetic process oligodendrocyte development neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis regulation of myelination secretory granule localization multicellular organism growth catenin import into nucleus regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth positive regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated negative regulation of organ growth positive regulation of lipid biosynthetic process embryonic digestive tract morphogenesis embryonic hindgut morphogenesis regulation of skeletal muscle tissue development regulation of oligodendrocyte differentiation positive regulation of epithelial cell proliferation face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus insulin metabolic process
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