Invitrogen

TCR beta Monoclonal Antibody (H57-597), PE

TCR beta Antibody in Flow Cytometry (Flow)

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TCR beta Antibody (MA5-17653) in Flow

Flow cytometric analysis of Splenic T cells (A) and Thymus cells (B) stained using anti-TCR alpha/beta Monoclonal Antibody (Product # MA5-17653) at a 1.0 µg/10^6 cells dilution. The Isotype control was a PE Hamster IgG

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产品信息

MA5-17653

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.2-1.0 µg/1x10^6 cells

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其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Armenian hamster / IgG

分类

Monoclonal

类型

Antibody

克隆号

H57-597

抗原

Affinity-purified DO-11.10 TCR

偶联物

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539043

靶标信息

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.

Oncotarget

Wei Y,Lu C,Chen J,Cui G,Wang L,Yu T,Yang Y,Wu W,Ding Y,Li L,Uede T,Chen Z,Diao H

MA517653 was used in flow cytometry to determine the effect of a high salt diet on intestinal immunity and the risk of inflammatory bowel disease

Tue Jan 03 00:00:00 EST 2017

Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells.

Brain, behavior, and immunity

Mandal M,Marzouk AC,Donnelly R,Ponzio NM

MA5-17653 was used in flow cytometry to examine how maternal immune stimulation affects the adaptive immune system and pathobiology of the offspring

Fri Jul 01 00:00:00 EDT 2011

Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.

Journal of immunology (Baltimore, Md. : 1950)

Cawthon AG,Alexander-Miller MA

MA5-17653 was used in flow cytometry to investigate the control of functional avidity in response to viral infection.

Tue Oct 01 00:00:00 EDT 2002

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hayashi K,Natsume W,Watanabe T,Abe N,Iwai N,Okada H,Ito Y,Asano M,Iwakura Y,Habu S,Takahama Y,Satake M

MA5-17653 was used in flow cytometry to investigate the role of AML1 in T cell development.

Fri Dec 15 00:00:00 EST 2000

Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay.

The Journal of experimental medicine

Ikawa T,Kawamoto H,Fujimoto S,Katsura Y

MA5-17653 was used in flow cytometry to describe a clonal system that supports the development of T and natural killer cells evenly.

Mon Dec 06 00:00:00 EST 1999

Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.

Proceedings of the National Academy of Sciences of the United States of America

Dejbakhsh-Jones S,Strober S

MA5-17653 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.

Tue Dec 07 00:00:00 EST 1999

Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver.

Journal of immunology (Baltimore, Md. : 1950)

Kawamoto H,Ohmura K,Fujimoto S,Katsura Y

MA5-17653 was used in flow cytometry to assess if progenitors colonizing the thymus are T cell lineage restricted.

Mon Mar 01 00:00:00 EST 1999

Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse.

Journal of immunology (Baltimore, Md. : 1950)

Ohmura K,Kawamoto H,Fujimoto S,Ozaki S,Nakao K,Katsura Y

MA5-17653 was used in flow cytometry to investigate the aorta-gonad-mesonephros region as a source of hemopoietic progenitors.

Mon Nov 01 00:00:00 EST 1999

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

The Journal of experimental medicine

Pear WS,Aster JC,Scott ML,Hasserjian RP,Soffer B,Sklar J,Baltimore D

MA5-17653 was used in flow cytometry to report that TAN1 is an oncoprotein.

Wed May 01 00:00:00 EDT 1996

Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules.

European journal of immunology

Ohteki T,Iwamoto M,Izui S,MacDonald HR

MA5-17653 was used in flow cytometry to examine the origin of double negative T cells using Ipr mice.

Sun Jan 01 00:00:00 EST 1995

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

The Journal of experimental medicine

Ohteki T,MacDonald HR

MA5-17653 was used in flow cytometry to investigate T cell subsets in the liver.

Mon Aug 01 00:00:00 EDT 1994

生物信息学

蛋白别名: bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; TCRbeta; TCRD; TRA

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基因别名: TCRbeta; Tib

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Entrez Gene ID: (Mouse) 21577

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TCR beta Monoclonal Antibody (H57-597), PE

TCR beta Antibody (MA5-17653) in Flow

产品信息

MA5-17653

流式细胞分析 (Flow)

其他PubMed (Misc)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

激发/发射光谱

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

靶标信息

How to use the Panel Builder

生物信息学

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