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NeoBiotechnologies
TDRKH Monoclonal Antibody (PCRP-TDRKH-1H2)
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产品信息
11022-MSM1-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
PCRP-TDRKH-1H2
抗原
Recombinant full-length human TDRKH protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: HeLa or MCF7 cells.Human testis or brain. Cellular Localization: Cytoplasm. Localized to cytosol and centrosome.
Specificity Comments: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Predicted to react with Mouse and Rat
靶标信息
TDRKH is a protein of unknown function containing one tudor domain, and two KH domains. It has been found to interact with PIWIL1 and PIWIL4 by binding to methylated arginines residues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: putative RNA binding protein; RP11-98D18.8; TDRD7; tudor and KH domain containing protein; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2
基因别名: TDRD2; TDRKH
UniProt ID: (Human) Q9Y2W6
Entrez Gene ID: (Human) 11022
