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Proteintech
TFAP2A/AP-2 Polyclonal Antibody
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产品信息
13019-3-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TFAP2A,AP-2 Fusion Protein Ag4112 (79-431 aa encoded by BC017754)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LHAQPQPQH PGWPGQRQSQ ESGLLHTHRG LPHQLSGLDP RRDYRRHEDL LHGPHALSSG LGDLSIHSLP HAIEEVPHVE DPGINIPDQT VIKKGPVSLS KSNSNAVSAI PINKDNLFGG VVNPNEVFCS VPGRLSLLSS TSKYKVTVAE VQRRLSPPEC LNASLLGGVL RRAKSKNGGR SLREKLDKIG LNLPAGRRKA ANVTLLTSLV EGEAVHLARD FGYVCETEFP AKAVAEFLNR QHSDPNEQVT RKNMLLATKQ ICKEFTDLLA QDRSPLGNSR PNPILEPGIQ SCLTHFNLIS HGFGSPAVCA AVTALQNYLT EALKAMDKMY LSNNPNSHTD NNAKSSDKEE KHRK (79-431 aa encoded by BC017754)
靶标信息
TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; ERF-1; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha
基因别名: AP-2; AP-2alpha; AP2TF; BOFS; TFAP2; TFAP2A
UniProt ID: (Human) P05549
Entrez Gene ID: (Human) 7020
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription coactivator activity
protein binding
transcription factor binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
kidney development
optic vesicle morphogenesis
optic cup structural organization
transcription from RNA polymerase II promoter
sensory perception of sound
negative regulation of cell proliferation
response to water deprivation
positive regulation of gene expression
retina layer formation
negative regulation of transcription by competitive promoter binding
Schwann cell development
trigeminal nerve development
oculomotor nerve formation
positive regulation of bone mineralization
response to lipopolysaccharide
embryonic forelimb morphogenesis
inner ear morphogenesis
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
palate development
bone morphogenesis
eyelid development in camera-type eye
positive regulation of tooth mineralization
cellular response to iron ion
negative regulation of reactive oxygen species metabolic process
