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Proteintech
TFEB Polyclonal Antibody
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产品信息
13372-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TFEB Fusion Protein Ag4194 (1-476 aa encoded by BC032448)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This is a rabbit polyclonal antibody raised against the full length of human TFEB. The calculated molecular weight of TFEB is 53 kDa, but modified TFEB is about 65-70 kDa.
Immunogen sequence: MASRIGLRM QLMREQAQQE EQRERMQQQA VMHYMQQQQQ QQQQQLGGPP TPAINTPVHF QSPPPVPGEV LKVQSYLENP TSYHLQQSQH QKVREYLSET YGNKFAAHIS PAQGSPKPPP AASPGVRAGH VLSSSAGNSA PNSPMAMLHI GSNPERELDD VIDNIMRLDD VLGYINPEMQ MPNTLPLSSS HLNVYSSDPQ VTASLVGVTS SSCPADLTQK RELTDAESRA LAKERQKKDN HNLIERRRRF NINDRIKELG MLIPKANDLD VRWNKGTILK ASVDYIRRMQ KDLQKSRELE NHSRRLEMTN KQLWLRIQEL EMQARVHGLP TTSPSGMNMA ELAQQVVKQE LPSEEGPGEA LMLGAEVPDP EPLPALPPQA PLPLPTQPPS PFHHLDFSHS LSFGGREDEG PPGYPEPLAP GHGSPFPSLS KKDLDLMLLD DSLLPLASDP LLSTMSPEAS KASSRRSSFS MEEGDVL (1-476 aa encoded by BC032448)
靶标信息
The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha TCFEB; bHLHe35; Class E basic helix-loop-helix protein 35; RP4-696P19.3; T-cell transcription factor EB; Transcription factor EB
基因别名: ALPHATFEB; BHLHE35; TCFEB; TFEB
UniProt ID: (Human) P19484, (Mouse) Q9R210
Entrez Gene ID: (Human) 7942, (Rat) 316214, (Mouse) 21425
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein heterodimerization activity
embryonic placenta development
adaptive immune response
transcription, DNA-templated
regulation of transcription, DNA-templated
autophagy
humoral immune response
lysosome organization
positive regulation of autophagy
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
immune system process
