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Product Details
PA5-17942
产品规格
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide sequence (VKIAYEEIFVKNM) corresponding to the C-terminus amino acids of TFPI
Conjugate
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_10988663
Target Information
Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: anti-convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein-associated coagulation inhibitor; OTTHUMP00000163472; OTTHUMP00000205431; TFPI; Tissue factor pathway inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Gene Aliases: EPI; LACI; TFI; TFPI; TFPI1
UniProt ID: (Human) P10646
Entrez Gene ID: (Human) 7035
Molecular Function:
protease inhibitor
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