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For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1; TALE homeobox TG-interacting factor; TGFB-induced factor homeobox 1; transforming growth factor-beta-induced factor
基因别名: HPE4; TGIF; TGIF1
UniProt ID: (Human) Q15583
Entrez Gene ID: (Human) 7050
分子生物学功能: homeodomain transcription factor