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Invitrogen
THRA/THRB Monoclonal Antibody (C3)
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THRA/THRB Antibody (MA1-215) in ICC/IF
Immunofluorescent analysis of Thyroid Hormone Receptor in HepG2 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a Thyroid Hormone Receptor monoclonal antibody (Product # MA1-215) at a dilution of 1:20 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). Thyroid ... View More
产品信息
MA1-215
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Hamster,
Human,
Mouse,
Non-human primate,
Rat,
Xenopus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
C3
抗原
Purified fragment of human TR beta-1 corresponding to residues 201-456.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-215 detects thyroid hormone receptor (TR) from human tissues. This antibody recognizes TR beta-1 and also cross-reacts with TR alpha-1.
MA1-215 has been successfully used in Western blot, IF, immunoprecipitation, and gel shift procedures. By Western blot, this antibody detects a 55 and a 52 kDa protein representing recombinant human TR beta-1 expressed in E. coli. MA1-215 immunoprecipitates 52 kDa and 55 kDa proteins, representing TR beta-1 and a 48 kDa protein representing TR alpha-1 expressed in E. coli.
The MA1-215 immunogen is a purified fragment of human TR beta-1 corresponding to amino acid residues 201-456. This antibody recognizes an epitope in the hormone binding domain of hTR beta-1, amino acid residues 235-414. This sequence is conserved in hTR alpha-1.
靶标信息
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c-erbA protooncogene; c-erbA-1; c-erbA-2; c-erbA-alpha; c-erbA-beta; EAR-7; ERBA-related 7; nuclear receptor; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; THRA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; Thyroid hormone receptor beta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7
基因别名: AR7; c-erbA; c-ERBA-1; C-ERBA-2; C-ERBA-BETA; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; THR1; THRA; THRA1; THRA2; THRalpha; THRalpha1; THRalpha2; THRB; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2; TRalpha; TRalpha1; TRalpha2; TRb; TRbeta; TRbeta1
UniProt ID: (Human) P10827, (Human) P10828
Entrez Gene ID: (Human) 7067, (Human) 7068
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
TBP-class protein binding
protein domain specific binding
chromatin DNA binding
sequence-specific DNA binding
macromolecular complex binding
metal ion binding
thyroid hormone binding
general transcription initiation factor binding
transcription coactivator binding
chromatin binding
enzyme binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
thyroid hormone mediated signaling pathway
positive regulation of thyroid hormone receptor signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
sensory perception of sound
negative regulation of female receptivity
regulation of heart contraction
female courtship behavior
organ morphogenesis
cell differentiation
mRNA transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinal cone cell development
retinoic acid receptor signaling pathway
Type I pneumocyte differentiation
cellular response to thyroid hormone stimulus
retinal cone cell apoptotic process
cartilage condensation
ossification
regulation of thyroid hormone mediated signaling pathway
transcription from RNA polymerase II promoter
learning or memory
response to cold
hormone-mediated signaling pathway
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
erythrocyte differentiation
thyroid gland development
regulation of myeloid cell apoptotic process
positive regulation of female receptivity
regulation of lipid catabolic process
positive regulation of cold-induced thermogenesis
negative regulation of DNA-templated transcription, initiation
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