Immunogen sequence: EGHVVKCYWG KESPDMTKNF QQVDYSQWGQ WSQVYGNPQQ YGQYMANGWQ VPPYGVYGQP WNQQGFGVDQ SPSAAWMGGF GAQPPQGQAP PPVIPPPNQA GYGMASYQTQ; Positive Samples: A-549, HeLa, K-562; Cellular Location: Cytoplasm, Cytoplasmic granule, Nucleus
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.
蛋白别名: aging-associated gene 7 protein; Nucleolysin TIAR; RNA binding protein TIAR (TIA-1 related); T-cluster binding protein; TIA-1-related nucleolysin; TIA-1-related protein; Tial 1 cytotoxic granule-associated RNA- binding protein-like 1; Tial1 cytotoxic granule-associated RNA binding protein-like 1; Tial1 cytotoxic granule-associated RNA-binding protein-like 1
基因别名: 5330433G13Rik; AL033329; mTIAR; TCBP; TIAL1; TIAR
分子生物学功能: translation initiation factor