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Agrisera
TIP1-1, TIP1-2/tonoplast intrinistic protein 1-1, 1-2 (gamma) Polyclonal Antibody
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TIP1-1, TIP1-2/tonoplast intrinistic protein 1-1, 1-2 (gamma) Antibody (AS22-4844) in WB
7.5 µg / 37.5 µg and 75 µg of total protein extracted freshly isolated from whole leaf extracts o Arabidopsis thaliana wt plants. Material was grinded frozen and then mixed 1:4 with cold isolation buffer (20 m M Tris p H 7.6,80 m M Na Cl, 0.7 m M EDTA, 5 m M Mg Cl, 1 m M DTT and 2% SDS). Protein concentration was measured by Bradford and sample was mixed 1:1 with loading dye (Bromphenolblue with 4%SDS and 2... View More
产品信息
AS22-4844
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide conserved in Raphanus sativus TIP1;1 and TIP1;2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Oryza sativa
靶标信息
TIP1 encodes a membrane-associated S-acyl transferase that localizes to endomembrane compartments and functions broadly in plant cell expansion, with especially prominent roles in polarized tip growth of root hairs and pollen tubes; loss-of-function alleles (tip1-1 and tip1-2) cause short, frequently branched root hairs, impaired pollen tube growth, and overall growth defects, consistent with a requirement for TIP1 activity in both tip growth and diffuse (non-tip) cell growth. Structurally, TIP1 is an ankyrin repeat-containing DHHC cysteine-rich domain protein (a DHHC palmitoyltransferase family member), with multiple N-terminal ankyrin repeats that are thought to mediate protein-protein interactions and a conserved DHHC catalytic motif within a cysteine-rich region that binds palmitate and supports enzymatic S-acylation; in functional assays, TIP1 can substitute for a yeast S-acyl transferase mutant and chemical inhibition of protein acylation phenocopies the tip1 root-hair defect, linking its molecular activity to growth control. Biologically, TIP1-dependent S-acylation is expected to regulate the membrane association, trafficking, and/or spatial activity of proteins required for cell surface expansion and polarized secretion, providing a mechanistic basis for its impact on root hair morphogenesis and general plant growth, and is distinct from tonoplast aquaporin TIP1;1 and TIP1;2, whose complete loss produces only mild physiological effects under standard conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gamma tonoplast intrinsic protein; gamma tonoplast intrinsic protein 1; GAMMA-TIP; GAMMA-TIP1; GAMMA-TIP2; GAMMA-TONOPLAST INTRINSIC PROTEIN; SALT-STRESS INDUCIBLE PROTEIN; SALT-STRESS INDUCIBLE TONOPLAST INTRINSIC PROTEIN; SITIP; T1J8.1; T1J8_1; TIP1;1; TIP1;2; TIP2; TONOPLAST INTRINSIC PROTEIN 1;1; tonoplast intrinsic protein 2
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