Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
蛋白别名: E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; Grg-1; Groucho-related protein 1; RP11-203D19.1; TLE 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like; Transducin-like enhancer protein 1
基因别名: C230057C06Rik; ESG; ESG1; Estm14; Grg-1; GRG1; TLE1; Tle4l
分子生物学功能: transcription cofactor