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Proteintech
TLK1 Polyclonal Antibody
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产品信息
13564-1-AP
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TLK1 Fusion Protein Ag4440 (456-766 aa encoded by BC032657)
偶联物
形式
Liquid
浓度
0.13 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: YLLLHLLGR GGFSEVYKAF DLYEQRYAAV KIHQLNKSWR DEKKENYHKH ACREYRIHKE LDHPRIVKLY DYFSLDTDTF CTVLEYCEGN DLDFYLKQHK LMSEKEARSI VMQIVNALRY LNEIKPPIIH YDLKPGNILL VDGTACGEIK ITDFGLSKIM DDDSYGVDGM DLTSQGAGTY WYLPPECFVV GKEPPKISNK VDVWSVGVIF FQCLYGRKPF GHNQSQQDIL QENTILKATE VQFPVKPVVS SEAKAFIRRC LAYRKEDRFD VHQLANDPYL LPHMRRSNSS GNLHMAGLTA SPTPPSSSII TY (456-766 aa encoded by BC032657)
靶标信息
TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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