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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: PKU beta; PKU-beta; Serine/threonine-protein kinase tousled-like 1; SNAK; TLK-1; TLK1B; Tousled-like kinase 1
基因别名: 4930545J15Rik; KIAA0137; TLK1
UniProt ID: (Mouse) Q8C0V0
Entrez Gene ID: (Rat) 311118, (Mouse) 228012