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Invitrogen
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), Biotin
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产品信息
MA5-49115
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
MTS510
抗原
Ba/F3 cells expressing mouse TLR4 and MD-2
偶联物
形式
Liquid
浓度
100 µg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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