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Abnova
TM6SF2 Polyclonal Antibody, MaxPab™
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产品信息
H00053345-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TM6SF2 (AAI60089.1, 1 a.a. approximately 377 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDIPPLAGKI AALSLSALPV SYALNHVSAL SHPLWVALMS ALILGLLFVA VYSLSHGEVS YDPLYAVFAV FAFTSVVDLI IALQEDSYVV GFMEFYTKEG EPYLRTAHGV FICYWDGTVH YLLYLAMAGA ICRRKRYRNF GLYWLGSFAM SILVFLTGNI LGKYSSEIRP AFFLTIPYLL VPCWAGMKVF SQPRALTRCT ANMVQEEQRK GLLQRPADLA LVIYLILAGF FTLFRGLVVL DCPTDACFVY IYQYEPYLRD PVAYPKVQML MYMFYVLPFC GLAAYALTFP GCSWLPDWAL VFAGGIGQAQ FSHMGASMHL RTPFTYRVPE DTWGCFFVCN LLYALGPHLL AYRCLQWPAF FHQPPPSDPL ALHKKQH
靶标信息
The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Transmembrane 6 superfamily member 2
基因别名: TM6SF2
UniProt ID: (Human) Q9BZW4
Entrez Gene ID: (Human) 53345
