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Immunogen sequence: LDSSCFSSPP VNFLQELPSY RSIARRRTTV HSRDKQSGTL LKPTDSYSSQ LEDRIAENLS SHSLRNYALN ISEKRRLRDI QETQMKYLSE WDQWKRYSSK SWKRFLEKAR EMTTHLE
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
TMC7 (Transmembrane channel-like protein 7) is a 723 amino acid protein that is a member of the TMC protein family. All TMC genes encode transmembrane proteins with intracellular amino- and carboxy- termini and at least eight membrane spanning domains. Therefore, TMC7 is a multi-pass membrane protein that may regulate or function as an ion channel or transporter. The gene encoding TMC7 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: transmembrane channel-like 7; Transmembrane channel-like protein 7
基因别名: TMC7
UniProt ID: (Human) Q7Z402
Entrez Gene ID: (Human) 79905