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Proteintech
TMEM59 Polyclonal Antibody
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产品信息
24134-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TMEM59 Fusion Protein Ag21150 (1-324 aa encoded by BC016374)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAPKGSLW VRTQLGLPPL LLLTMALAGG SGTASAEAFD SVLGDTASCH RACQLTYPLH TYPKEEELYA CQRGCRLFSI CQFVDDGIDL NRTKLECESA CTEAYSQSDE QYACHLGCQN QLPFAELRQE QLMSLMPKMH LLFPLTLVRS FWSDMMDSAQ SFITSSWTFY LQADDGKIVI FQSKPEIQYA PHLEQEPTNL RESSLSKMSS DLQMRNSQAH RNFLEDGESD GFLRCLSLNS GWILTTTLVL SVMVLLWICC ATVATAVEQY VPSEKLSIYG DLEFMNEQKL NRYPASSLVV VRSKTEDHEE AGPLPTKVNL AHSEI (1-324 aa encoded by BC016374)
靶标信息
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Transmembrane protein 59
基因别名: C1orf8; DCF1; HSPC001; PRO195; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4
Entrez Gene ID: (Human) 9528
