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Bioss
TMEM59 Polyclonal Antibody
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产品信息
BS-11647R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human TMEM59, amino acids 141-240.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Thymic dendritic cell-derived factor 1; Transmembrane protein 59
基因别名: 1110001M20Rik; 3110046P06Rik; AI256529; C1orf8; D4Ertd20e; DCF1; HSPC001; MTDCF1; ORF18; PRO195; RGD1310313; Tdcf1; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4, (Mouse) Q9QY73
Entrez Gene ID: (Human) 9528, (Mouse) 56374, (Rat) 100196907
