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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
1:50-1:200 | - |
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein corresponding to Human TMEM8A |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2648739 |
Immunogen sequence: TCAYVFQPEL LVTRVVEISI MEPDVPLPQT LLSHPSYLKV FVPDYTRELL LELRDCVSNG SLGCPVRLTV GPVTLPSNFQ KVL
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 75%.
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: five-span transmembrane protein M83; GPI processing phospholipase A2; GPI-PLA2; Post-GPI attachment to proteins factor 6; Protein M83; Transmembrane protein 6; Transmembrane protein 8; transmembrane protein 8 (five membrane-spanning domains); Transmembrane protein 8A
基因别名: M83; PGAP6; TMEM6; TMEM8; TMEM8A
UniProt ID: (Human) Q9HCN3
Entrez Gene ID: (Human) 58986
分子生物学功能:
cell adhesion molecule
