Peptide sequence: RSSFQLLNVE YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA
Sequence homology: Guinea Pig: 79%; Horse: 79%; Human: 100%; Rabbit: 79%
The interleukin 17 receptor E (IL-17RE) shares limited similarity to the receptor of IL-17A, a ubiquitous type I membrane glycoprotein that with IL-17A plays a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RE is the functional receptor of IL-17C and has been suggested to mediate mucosal immunity to infection with intestinal pathogens. IL-17C is produced by epithelia in response to bacterial challenge and binds to a receptor complex formed by IL-17RE and IL-17RA on the epithelial cell surface, thereby regulating the immune function of epithelial cells in an autocrine manner.
蛋白别名: airway trypsin like protease; Airway trypsin-like protease; MGC150587; MGC150588; Transmembrane protease serine 11D; Transmembrane protease serine 11D catalytic chain; Transmembrane protease serine 11D non-catalytic chain
基因别名: HAT; TMPRSS11D
UniProt ID: (Human) O60235
Entrez Gene ID: (Human) 9407
分子生物学功能: serine protease