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Invitrogen
TNF alpha Antibody Cocktail
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TNF alpha Antibody (AHC3712) in ELISA
The Journal of experimental medicine 1999 -
Figure 3 CT treatment selectively suppressed IL-12 p70 and TNF-alpha, but not IL-10, TGF-beta 1 , or IL-6. Human monocytes (2 x 10 6 cell/mL) were stimulated with SAC (0.01%) and IFN-gamma (100 ng/mL) in the presence or absence of CT (10 ng/mL). Cytokine production was measured by ELISA 24 h after stimulation. Data are mean values +- SD of four separate experiments using four different donors. ** P <... View More
产品信息
AHC3712
应用
建议稀释比
已发表文章
产品规格
已发表种属
Bacteria,
Human
宿主/亚型
Mouse
/ Ig Mix
分类
Cocktail
类型
Antibody
克隆号
68B2B3 and 68B6A3
抗原
Purified recombinant human TNF-alpha.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This monoclonal mixture is recommended as a capture antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 68B 2B3 BC6/68B 6A3 1H8 1F2.
Clone 68B2B3 isotype is undetermined. Clone 68B6A3 isotype is IgG1.
靶标信息
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
