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Invitrogen
TNF alpha Monoclonal Antibody (E10011)
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产品信息
MBOTNFAI
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
E10011
抗原
Recombinant bovine TNF alpha purified from Pichia pastoris
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
500 µg
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
MBOTNFAI targets TNF Alpha in ELISA, and WB applications and shows reactivity with Bovine samples.
The MBOTNFAI immunogen is recombinant bovine TNFa purified from Pichia pastoris.
MBOTNFAI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa.
The MBOTNFAI bovine TNFa monoclonal antibody (clone E10011) has successfully been paired as the coating antibody in a sandwich ELISA with biotinylated polyclonal detection antibody PBOTNFABI . Typical dilutions for sandwich ELISA include 1 µg/mL for coating and 0.125 - 0.25 µg/mL for detection.
Endotoxin levels are less than or equal to 10 µg/mL
靶标信息
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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