Invitrogen

TNF alpha Monoclonal Antibody (MAb11), APC, eBioscience™

TNF alpha Antibody in Flow Cytometry (Flow)

图: 1 / 28

TNF alpha Antibody (17-7349-82) in Flow

Normal human peripheral blood cells were unstimulated (left) or stimulated for 5 hours with Cell Stimulation Cocktail (plus protein transport inhibitors) (Product # 00-4975-03) (right). Cells were intracellularly stained with Anti-Human CD4 PerCP-eFluor® 710 (Product # 46-0047-42) and Anti-Human TNF alpha APC using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Cells in the lymphocyte gate were used for analysis.

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产品信息

17-7349-82

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.25 µg/test

查看43篇已发表文章 43篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Rhesus monkey

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

MAb11

偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_469512

产品详细信息

Description: The MAb11 antibody reacts with human tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4+ T cells. TN alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF alpha forms dimers and trimers and also exists as a 26 kDa membrane bound form. The MAb11 antibody is a neutralizing antibody.

Applications Reported:MAb11 has been reported for use in intracellular flow cytometric analysis.

Applications Tested: Has been tested by intracellular staining and flow cytometric analysis of stimulated human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

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Dynamics of humoral and cellular response to three doses of anti-SARS-CoV-2 BNT162b2 vaccine in patients with hematological malignancies and older subjects.

Frontiers in immunology

Laquintana V,Mottini C,Marchesi F,Marcozzi B,Terrenato I,Sperandio E,de Latouliere L,Carrieri F,Pimpinelli F,Pontone M,Pellini R,Campo F,Conti L,Accetta C,Mandoj C,Petrone F,Di Bella O,Vujovic B,Morrone A,Compagnone M,Principato E,Pinto E,Papa E,Falcucci P,La Malfa A,Pallocca M,De Marco F,Piaggio G,Ciliberto G,Mengarelli A,di Martino S

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Wed Feb 14 00:00:00 UTC 2024

R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.

iScience

Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Fri Jun 16 00:00:00 UTC 2023

An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response.

Molecular therapy oncolytics

Zeng L,Zheng W,Zhang J,Wang J,Ji Q,Wu X,Meng Y,Zhu X

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Dec 19 00:00:00 UTC 2023

LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.

Cell death & disease

Li H,Yang Z,Yang X,Zhang F,Wang J,Wu Z,Wanyan C,Meng Q,Gao W,Yang X,Wei J

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Thu Feb 03 00:00:00 UTC 2022

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.

Nature communications

Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Mon Dec 12 00:00:00 UTC 2022

Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection.

Cell reports. Medicine

Jeong HW,Kim SM,Jung MK,Noh JY,Yoo JS,Kim EH,Kim YI,Yu K,Jang SG,Gil J,Casel MA,Rare R,Choi JH,Kim HS,Kim JH,Um J,Kim C,Kim Y,Chin BS,Jung S,Choi JY,Song KH,Kim YD,Park JS,Song JY,Shin EC,Choi YK

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Oct 18 00:00:00 UTC 2022

Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques.

Cell reports

Rhoades NS,Davies M,Lewis SA,Cinco IR,Kohama SG,Bermudez LE,Winthrop KL,Fuss C,Mattison JA,Spindel ER,Messaoudi I

17-7349-82 was used in flow cytometry to provide insight into age-related changes in the lungs' functional, microbial, and immunological landscape that explain increased prevalence and severity of respiratory diseases in the elderly.

Tue Apr 19 00:00:00 UTC 2022

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.

Cell

Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Nekorchuk M,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MYH,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Filev PD,Weiskopf D,Silvestri G,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Thu Jan 21 00:00:00 UTC 2021

Membrane lymphotoxin-α₂β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist.

Cell death & disease

Kucka K,Lang I,Zhang T,Siegmund D,Medler J,Wajant H

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Apr 06 00:00:00 UTC 2021

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca²⁺ entry in T cells.

Cell reports

Wu B,Woo JS,Vila P,Jew M,Leung J,Sun Z,Srikanth S,Gwack Y

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Aug 24 00:00:00 UTC 2021

Development of an Inflammatory CD14⁺ Dendritic Cell Subset in Humanized Mice.

Frontiers in immunology

Iwabuchi R,Ide K,Terahara K,Wagatsuma R,Iwaki R,Matsunaga H,Tsunetsugu-Yokota Y,Takeyama H,Takahashi Y

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Mon Sep 27 00:00:00 UTC 2021

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.

Nature medicine

Apostolidis SA,Kakara M,Painter MM,Goel RR,Mathew D,Lenzi K,Rezk A,Patterson KR,Espinoza DA,Kadri JC,Markowitz DM,E Markowitz C,Mexhitaj I,Jacobs D,Babb A,Betts MR,Prak ETL,Weiskopf D,Grifoni A,Lundgreen KA,Gouma S,Sette A,Bates P,Hensley SE,Greenplate AR,Wherry EJ,Li R,Bar-Or A

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Mon Nov 01 00:00:00 UTC 2021

Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory-Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand.

Cancer research communications

Ando M,Kondo T,Tomisato W,Ito M,Shichino S,Srirat T,Mise-Omata S,Nakagawara K,Yoshimura A

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Fri Oct 01 00:00:00 UTC 2021

Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy.

iScience

Sureshchandra S,Marshall NE,Mendoza N,Jankeel A,Zulu MZ,Messaoudi I

17-7349-82 was used in Flow Cytometry to provide novel insight into the increased susceptibility to infections in women with obesity during pregnancy and following cesarean delivery.

Fri Jun 25 00:00:00 UTC 2021

Broad and strong memory CD4⁺ and CD8⁺ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.

Nature immunology

Peng Y,Mentzer AJ,Liu G,Yao X,Yin Z,Dong D,Dejnirattisai W,Rostron T,Supasa P,Liu C,López-Camacho C,Slon-Campos J,Zhao Y,Stuart DI,Paesen GC,Grimes JM,Antson AA,Bayfield OW,Hawkins DEDP,Ker DS,Wang B,Turtle L,Subramaniam K,Thomson P,Zhang P,Dold C,Ratcliff J,Simmonds P,de Silva T,Sopp P,Wellington D,Rajapaksa U,Chen YL,Salio M,Napolitani G,Paes W,Borrow P,Kessler BM,Fry JW,Schwabe NF,Semple MG,Baillie JK,Moore SC,Openshaw PJM,Ansari MA,Dunachie S,Barnes E,Frater J,Kerr G,Goulder P,Lockett T,Levin R,Zhang Y,Jing R,Ho LP,Cornall RJ,Conlon CP,Klenerman P,Screaton GR,Mongkolsapaya J,McMichael A,Knight JC,Ogg G,Dong T

17-7349-82 was used in Flow cytometry/Cell sorting to study T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1.

Sun Nov 01 00:00:00 UTC 2020

Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma.

Molecular therapy oncolytics

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Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Fri Mar 27 00:00:00 UTC 2020

Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy.

Scientific reports

Lee J,Sheen JH,Lim O,Lee Y,Ryu J,Shin D,Kim YY,Kim M

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Oct 20 00:00:00 UTC 2020

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis.

eLife

Trivedi S,Labuz D,Anderson CP,Araujo CV,Blair A,Middleton EA,Jensen O,Tran A,Mulvey MA,Campbell RA,Hale JS,Rondina MT,Leung DT

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Mon Nov 09 00:00:00 UTC 2020

CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions.

International journal of molecular sciences

Huang BR,Liu YS,Lai SW,Lin HJ,Shen CK,Yang LY,Lu DY

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Fri Aug 14 00:00:00 UTC 2020

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors.

Nature communications

Webber BR,Lonetree CL,Kluesner MG,Johnson MJ,Pomeroy EJ,Diers MD,Lahr WS,Draper GM,Slipek NJ,Smeester BA,Lovendahl KN,McElroy AN,Gordon WR,Osborn MJ,Moriarity BS

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Tue Nov 19 00:00:00 UTC 2019

Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women.

PloS one

Splunter MV,Perdijk O,Fick-Brinkhof H,Floris-Vollenbroek EG,Meijer B,Brugman S,Savelkoul HFJ,van Hoffen E,Joost van Neerven RJ

17-7349-82 was used in Flow Cytometry to confirm and extend the knowledge about immunosenescence and inflammageing on innate immunity in elderly women.

Wed Mar 25 00:00:00 UTC 2020

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.

Nature communications

Duhen T,Duhen R,Montler R,Moses J,Moudgil T,de Miranda NF,Goodall CP,Blair TC,Fox BA,McDermott JE,Chang SC,Grunkemeier G,Leidner R,Bell RB,Weinberg AD

17-7349 was used in Flow cytometry/Cell sorting to develop an approach for detecting tumour-reactive tumour-infiltrating CD8 T cells that will help define mechanisms of existing immunotherapy treatments.

Fri Jul 13 00:00:00 UTC 2018

Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.

Oncotarget

Morimoto S,Fujiki F,Kondo K,Nakajima H,Kobayashi Y,Inatome M,Aoyama N,Nishida Y,Tsuboi A,Oka Y,Nishida S,Nakata J,Hosen N,Oji Y,Sugiyama H

17-7349 was used in Flow cytometry/Cell sorting to develop a novel platform cell line, named 2D3, which enables the functional avidity of transduced T cell receptors to be evaluated efficiently and precisely.

Tue Sep 25 00:00:00 UTC 2018

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Cell

Jiménez-Sánchez A,Memon D,Pourpe S,Veeraraghavan H,Li Y,Vargas HA,Gill MB,Park KJ,Zivanovic O,Konner J,Ricca J,Zamarin D,Walther T,Aghajanian C,Wolchok JD,Sala E,Merghoub T,Snyder A,Miller ML

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Thu Aug 24 00:00:00 UTC 2017

The distribution and function of human memory T cell subsets in lung cancer.

Immunologic research

Sheng SY,Gu Y,Lu CG,Zou JY,Hong H,Wang R

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Thu Jun 01 00:00:00 UTC 2017

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population.

PloS one

Baguma R,Penn-Nicholson A,Smit E,Erasmus M,Day J,Makhethe L,de Kock M,Hughes EJ,van Rooyen M,Pienaar B,Stone L,Hanekom W,Brennan MJ,Wallis RS,Hatherill M,Scriba TJ

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Wed Oct 18 00:00:00 UTC 2017

Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes.

Journal of extracellular vesicles

Salimu J,Webber J,Gurney M,Al-Taei S,Clayton A,Tabi Z

17-7349 was used in Flow cytometry/Cell sorting to identify exosomal prostaglandin E2 as a driver of CD73 induction, as prostaglandin E2 receptor inhibition significantly reduced exosome-dependent CD73 induction.

Wed Sep 30 00:00:00 UTC 2020

Prostaglandin E₂-mediated adenosinergic effects on CD14⁺ cells: Self-amplifying immunosuppression in cancer.

Oncoimmunology

Al-Taei S,Salimu J,Spary LK,Clayton A,Lester JF,Tabi Z

17-7349 was used in Flow cytometry/Cell sorting to show that CD73 expression can be induced by PGE2, cAMP or adenosine on human CD14+ cells.

Tue Jan 12 00:00:00 UTC 2021

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.

PLoS pathogens

Tomić A,Varanasi PR,Golemac M,Malić S,Riese P,Borst EM,Mischak-Weissinger E,Guzmán CA,Krmpotić A,Jonjić S,Messerle M

17-7349 was used in Flow cytometry/Cell sorting to investigate a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses.

Thu Dec 01 00:00:00 UTC 2016

CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection.

European journal of immunology

Rölle A,Halenius A,Ewen EM,Cerwenka A,Hengel H,Momburg F

17-7349 was used in Flow cytometry/Cell sorting to explore whether CD2 was directly involved in the response of adaptive natural killer cells to human cytomegalovirus.

Sat Oct 01 00:00:00 UTC 2016

Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Journal of immunology (Baltimore, Md. : 1950)

Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V

17-7349 was used in Flow cytometry/Cell sorting to study the molecular signal that characterises an Eomeshi population of natural killer cells in the human liver that is not present in the blood.

Thu Dec 01 00:00:00 UTC 2016

The human CD8+ T cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes.

Journal of virology

Weiskopf D,Angelo MA,Bangs DJ,Sidney J,Paul S,Peters B,de Silva AD,Lindow JC,Diehl SA,Whitehead S,Durbin A,Kirkpatrick B,Sette A

17-7349 was used in Flow cytometry/Cell sorting to characterise the CD8(+) T cell responses after live attenuated dengue vaccination.

Thu Jan 01 00:00:00 UTC 2015

Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.

Stem cells (Dayton, Ohio)

Amarnath S,Foley JE,Farthing DE,Gress RE,Laurence A,Eckhaus MA,Métais JY,Rose JJ,Hakim FT,Felizardo TC,Cheng AV,Robey PG,Stroncek DE,Sabatino M,Battiwalla M,Ito S,Fowler DH,Barrett AJ

17-7349 was used in Flow cytometry/Cell sorting to investigate the mechanism of BMSC in treatment of alloimmune and autoimmune conditions, showing that they harness purinergenic signaling to tolerize human Th1 cells.

Wed Apr 01 00:00:00 UTC 2015

GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.

Oncoimmunology

Pedroza-Gonzalez A,Zhou G,Singh SP,Boor PP,Pan Q,Grunhagen D,de Jonge J,Tran TK,Verhoef C,IJzermans JN,Janssen H,Biermann K,Kwekkeboom J,Sprengers D

17-7349 was used in Flow cytometry/Cell sorting to investigate the ability of GITR-ligation and CTLA-4 blockade treatments to alleviate immunosuppression mediated by human liver tumor-derived regulatory T cells.

Tue Dec 01 00:00:00 UTC 2015

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.

Science signaling

Kusne Y,Carrera-Silva EA,Perry AS,Rushing EJ,Mandell EK,Dietrich JD,Errasti AE,Gibbs D,Berens ME,Loftus JC,Hulme C,Yang W,Lu Z,Aldape K,Sanai N,Rothlin CV,Ghosh S

17-7349 was used in Flow cytometry/Cell sorting to determine that targeting aPKC might provide an improved molecular approach for glioblastoma therapy.

Tue Aug 12 00:00:00 UTC 2014

HTLV-1 bZIP factor-specific CD4 T cell responses in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation.

Journal of immunology (Baltimore, Md. : 1950)

Narita T,Ishida T,Masaki A,Suzuki S,Ito A,Mori F,Yamada T,Ri M,Kusumoto S,Komatsu H,Miyazaki Y,Takatsuka Y,Utsunomiya A,Niimi A,Iida S,Ueda R

17734982 was used in flow cytometry to investigate human T lymphotropic virus type 1 bZIP factor-specific CD4 T cell responses

Sat Feb 01 00:00:00 UTC 2014

Cell-mediated immune responses to respiratory syncytial virus infection: magnitude, kinetics, and correlates with morbidity and age.

Human vaccines & immunotherapeutics

Geevarghese B,Weinberg A

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Mon Apr 25 00:00:00 UTC 2016

Functional OCT4-specific CD4⁺ and CD8⁺ T cells in healthy controls and ovarian cancer patients.

Oncoimmunology

Di J,Massuger LF,Duiveman-de Boer T,Zusterzeel PL,Figdor CG,Torensma R

Published figure using TNF alpha monoclonal antibody (Product # 17-7349-82) in Flow Cytometry

Wed May 01 00:00:00 UTC 2013

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.

Science translational medicine

Amarnath S,Mangus CW,Wang JC,Wei F,He A,Kapoor V,Foley JE,Massey PR,Felizardo TC,Riley JL,Levine BL,June CH,Medin JA,Fowler DH

17-7349 was used in Flow cytometry/Cell sorting to study how converting human T(H)1 cells to a regulatory phenotype with PD1 signaling provides a potential way to block GVHD after transplantation.

Wed Nov 30 00:00:00 UTC 2011

Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.

Infection and immunity

Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T

17-7349 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.

Sat Oct 01 00:00:00 UTC 2011

Differential expression of CD300a/c on human TH1 and TH17 cells.

BMC immunology

Simhadri VR,Mariano JL,Zhou Q,DeBell KE,Borrego F

17-7349 was used in Flow cytometry/Cell sorting to conclude that the CD300a/c receptors are differentially expressed on human TH1 and TH17 cells, and that their ligation is capable of modulating TCR mediated signals.

Wed Nov 02 00:00:00 UTC 2011

Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.

PloS one

Narayanan S,Silva R,Peruzzi G,Alvarez Y,Simhadri VR,Debell K,Coligan JE,Borrego F

17-7349 was used in Flow cytometry/Cell sorting to investigate a subset within the CD4 T cell population defined by expression of the immunomodulatory receptor CD300a.

Thu May 13 00:00:00 UTC 2010

生物信息学

蛋白别名: APC1 protein; Cachectin; DADB-70P7.1; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFα; Tumor necrosis factor; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

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基因别名: DIF; TNF; TNF-alpha; TNFA; TNFSF2; TNLG1F

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UniProt ID: (Human) P01375

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Entrez Gene ID: (Human) 7124

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功能

protease binding cytokine activity tumor necrosis factor receptor binding protein binding identical protein binding transcription regulatory region DNA binding

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