FIGURE: 1 / 5
Immunogen sequence: DRTGTSKCRK AGCVYFGTPE NKGFCTLCFI EYRENKHFAA ASGKVSPTAS RFQNTIPCLG RECGTLGSTM FEGYCQKCFI EAQNQRFHEA KRTEEQLRSS QRRDVPRTTQ STSRPKCARA SCKNILACRS EELCMECQH
Positive Samples: Jurkat, HepG2, SW480, Mouse spleen; Cellular Location: Cytoplasm, Lysosome, Nucleus
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
Protein Aliases: A20p37; A20p50; OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20
Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3; Tnfip3
Molecular Function: cysteine protease