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Product Details
PA5-63397
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant protein corresponding to Human TNFAIP8
Conjugate
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2648781
Product Specific Information
Immunogen sequence: AKSHGRVNNV FDHFSDCEFL AALYNPFGNF KPHLQKLCDG INKMLDEENI
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkappa B. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NDED; NF-kappa-B-inducible DED-containing protein; SCC S2; SCC-S2; TNF alpha-induced protein 8; TNF-induced protein GG2-1; TNFalpha IP8; TNFalpha-IP 8; TNFalphaIP8; Tumor necrosis factor alpha-induced protein 8; tumor necrosis factor, alpha induced protein 8; tumor necrosis factor, alpha-induced protein 8
Gene Aliases: GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2; TNFAIP8
UniProt ID: (Human) O95379
Entrez Gene ID: (Human) 25816
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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