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Invitrogen
TNFRSF11B Polyclonal Antibody
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产品信息
PA1-24881
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant, full length mouse protein, expressed in mouse NSO cells.
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-24881 detects Osteoprotegerin from mouse samples. PA1-24881 is expected to cross react with human (89% conserved) and rat (93% conserved) due to sequence homology.
PA1-24881 has been successfully used in neutralization, inhibition assays, and Western blot procedures. For Western blotting, use antibody in non-reducing conditions. The Neutralization Dose50 (ND50) for anti-mouse osteoprotegerin is 0.5-2 ug/ml in the presence of 0.1 ug/ml of soluble recombinant mouse OPG/Fc, using the TRAIL sensitive mouse L929 cytolytic assay.
The PA1-24881 immunogen is recombinant, full length mouse protein, expressed in mouse NSO cells.
靶标信息
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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