The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
蛋白别名: Receptor expressed in lymphoid tissues; Tumor necrosis factor receptor superfamily member 19L
基因别名: RELT; TNFRSF19L; TRLT
UniProt ID: (Human) Q969Z4
Entrez Gene ID: (Human) 84957
分子生物学功能: transmembrane signal receptor