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产品信息
PA5-64968
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human TOB2 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.05 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2663277 |
产品详细信息
Immunogen sequence: PELDKEIKSSF NPDAQVFVPI GSQDSSLSNS PSPSFGQSPS PTFIPRSAQP ITFTTASFAA TKFGSTKMKK GGGAASGGGV ASSGAGGQQP PQQPRMARSP TNSLLKHKSL SLSMHSLNFI TANPAPQSQL SPNAKEFVYN GGGSPSLFFD AADGQGSGTP GPFGGSGAGT CNSS
Highest antigen sequence identity to the following orthologs - mouse 86%, rat 88%.
靶标信息
TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein Tob2; Protein Tob4; Transducer of erbB-2 2
基因别名: APRO5; KIAA1663; TOB2; TOB4; TOBL; TROB2
UniProt ID: (Human) Q14106
Entrez Gene ID: (Human) 10766
