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TOPBP1 Antibody (PA5-96424) in IHC (P)
Immunohistochemistry analysis of TOPBP1 in paraffin-embedded human colon carcinoma. Samples were incubated with TOPBP1 Polyclonal antibody (Product # PA5-96424) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-96424
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1253-1522 of human TOPBP1.
偶联物
Unconjugated
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2808226
产品详细信息
Immunogen sequence: KIITIEETHE ELKKQYIFQL SSLNPQERID YCHLIEKLGG LVIEKQCFDP TCTHIVVGHP LRNEKYLASV AAGKWVLHRS YLEACRTAGH FVQEEDYEWG SSSILDVLTG INVQQRRLAL AAMRWRKKIQ QRQESGIVEG AFSGWKVILH VDQSREAGFK RLLQSGGAKV LPGHSVPLFK EATHLFSDLN KLKPDDSGVN IAEAAAQNVY CLRTEYIADY LMQESPPHVE NYCLPEAISF IQNNKELGTG LSQKRKAPTE KNKIKRPRVH; Positive Samples: 293T; Cellular Location: Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole
靶标信息
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; TOPBP 1; TopBP1; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
基因别名: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; KIAA0259; mKIAA0259; RGD1562949; TOP2BP1; TOPBP1
UniProt ID: (Human) Q92547, (Mouse) Q6ZQF0
Entrez Gene ID: (Human) 11073, (Mouse) 235559, (Rat) 315969
分子生物学功能:
DNA metabolism protein
nucleic acid metabolism protein
